Gene
map2k4a
- ID
- ZDB-GENE-060512-98
- Name
- mitogen-activated protein kinase kinase 4a
- Symbol
- map2k4a Nomenclature History
- Previous Names
-
- map2k4
- mkk4a (1)
- zgc:136500
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase activity. Acts upstream of or within determination of dorsal identity. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Seo et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Rui et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B0Q3 | InterPro | 393 | ||||
| UniProtKB:A0A8M2BBT8 | InterPro | 389 | ||||
| UniProtKB:B1NA68 | InterPro | 404 | ||||
| UniProtKB:A0AB32TAS3 | InterPro | 362 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map2k4a-201
(1)
|
Ensembl | 1,122 nt | ||
| mRNA |
map2k4a-202
(1)
|
Ensembl | 1,315 nt | ||
| mRNA |
map2k4a-203
(1)
|
Ensembl | 1,373 nt | ||
| mRNA |
map2k4a-204
(1)
|
Ensembl | 585 nt | ||
| mRNA |
map2k4a-205
(1)
|
Ensembl | 1,079 nt |
Interactions and Pathways
No data available
Plasmids
No data available