Gene
slc26a4
- ID
- ZDB-GENE-060503-544
- Name
- solute carrier family 26 member 4
- Symbol
- slc26a4 Nomenclature History
- Previous Names
-
- si:dkey-31f5.9
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have anion transmembrane transporter activity. Involved in anion homeostasis; chloride transport; and response to salt stress. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; and goiter. Is expressed in several structures, including gill; heart; liver; muscle; and pleuroperitoneal region. Orthologous to human SLC26A4 (solute carrier family 26 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal recessive nonsyndromic deafness 4 | Alliance | Deafness, autosomal recessive 4, with enlarged vestibular aqueduct | 600791 |
Pendred Syndrome | Alliance | Pendred syndrome | 274600 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | SLC26A/SulP transporter | SLC26A/SulP transporter domain | STAS domain | STAS domain superfamily | Sulphate anion transporter, conserved site |
---|---|---|---|---|---|---|
UniProtKB:A0A8M6Z5Y9
|
779 | |||||
UniProtKB:C8XTB7
|
760 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
slc26a4-201
(1)
|
Ensembl | 2280 nt | |
mRNA |
slc26a4-202
(1)
|
Havana | 2232 nt |
Interactions and Pathways
No data available
Plasmids
No data available