Gene
calcr
- ID
- ZDB-GENE-060503-420
- Name
- calcitonin receptor
- Symbol
- calcr Nomenclature History
- Previous Names
-
- CTR (1)
- si:ch211-77k19.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable calcitonin receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including eye; gill; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (calcitonin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lafont et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteoporosis | Alliance | {Osteoporosis, postmenopausal, susceptibility} | 166710 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR003287 | GPCR, family 2, calcitonin receptor family |
| Family | IPR050332 | G-protein coupled receptor 2 |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, family 2, calcitonin receptor family | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PPS1 | InterPro | 598 |
Interactions and Pathways
No data available
Plasmids
No data available