ZFIN is now using GRCz12tu for Genomic Data
Gene
ctbp1
- ID
- ZDB-GENE-060421-4235
- Name
- C-terminal binding protein 1
- Symbol
- ctbp1 Nomenclature History
- Previous Names
-
- fa96d06
- wu:fa96d06
- zgc:136929
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human CTBP1 (C-terminal binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome | 617915 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR029752 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 |
| Conserved_site | IPR029753 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site |
| Domain | IPR006139 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
| Domain | IPR006140 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain |
| Family | IPR043322 | C-terminal binding protein |
| Family | IPR051638 | C-terminal-binding dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C-terminal-binding dehydrogenase | C-terminal binding protein | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1RLQ4 | InterPro | 440 | |||||||
| UniProtKB:A0A2R8QPP7 | InterPro | 429 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctbp1-203
(1)
|
Ensembl | 2,024 nt | ||
| mRNA |
ctbp1-204
(1)
|
Ensembl | 2,131 nt | ||
| mRNA |
zgc:136929-201
(1)
|
Ensembl | 2,907 nt | ||
| mRNA |
zgc:136929-202
(1)
|
Ensembl | 1,374 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance