Gene

arhgef7a

ID

ZDB-GENE-060322-11

Name

Rho guanine nucleotide exchange factor (GEF) 7a

Symbol

arhgef7a Nomenclature History

Previous Names

fc28d09
wu:fc28d09

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm and lamellipodium. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144067 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef7a Human Ortholog

No data available

Associated With arhgef7a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001452	SH3 domain
Domain	IPR001715	Calponin homology domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR032409	Rho guanine nucleotide exchange factor 6/7, coiled-coil domain
Domain	IPR035788	Rho guanine nucleotide exchange factor 6, SH3 domain
Domain	IPR046376	RhoGEF 6/7, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Length	Calponin homology domain	CH domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PH-like domain superfamily	Pleckstrin homology domain	RhoGEF 6/7, PH domain	Rho guanine nucleotide exchange factor 6/7, coiled-coil domain	Rho guanine nucleotide exchange factor 6, SH3 domain	SH3 domain	SH3-like domain superfamily
UniProtKB:B0S771 InterPro	858
UniProtKB:A0A8M9QJM4 InterPro	702
UniProtKB:A0A2R8Q515 InterPro	859
UniProtKB:A0A8M6Z2J5 InterPro	782
UniProtKB:A0A8M2BF23 InterPro	807
UniProtKB:A0A8M2BF17 InterPro	777
UniProtKB:A0A8M9Q4K4 InterPro	864
UniProtKB:A0A8M2BEZ3 InterPro	802

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef7a-202 (1) Ensembl	Ensembl	3,312 nt	Select Tool ZFIN BLAST
mRNA	arhgef7a-204 (1) Ensembl	Ensembl	6,971 nt	Select Tool ZFIN BLAST
ncRNA	arhgef7a-002 (1) Ensembl	Ensembl	2,491 nt	Select Tool ZFIN BLAST
ncRNA	arhgef7a-003 (1) Ensembl	Ensembl	556 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations