Gene
camk2a
- ID
- ZDB-GENE-051113-72
- Name
- calcium/calmodulin-dependent protein kinase II alpha
- Symbol
- camk2a Nomenclature History
- Previous Names
-
- camk2a1 (1)
- zgc:112538
- zgc:123320
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables calcium/calmodulin-dependent protein kinase activity. Acts upstream of or within heart jogging and protein autophosphorylation. Predicted to be active in cytoplasm; neuron projection; and postsynaptic density. Is expressed in brain; heart; somite; and tail bud. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112538 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-camk2a | Bu et al., 2021 | |
| MO1-camk2a | N/A | (2) |
| MO2-camk2a | N/A | Francescatto et al., 2010 |
| MO3-camk2a | N/A | Roy et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 53 | Alliance | Intellectual developmental disorder, autosomal dominant 53 | 617798 |
| autosomal recessive intellectual developmental disorder 63 | Alliance | ?Intellectual developmental disorder, autosomal recessive 63 | 618095 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR013543 | Calcium/calmodulin-dependent protein kinase II, association-domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium/calmodulin-dependent protein kinase II, association-domain | NTF2-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q32PV2 | InterPro | 478 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
camk2a-201
(1)
|
Ensembl | 1,976 nt | ||
| mRNA |
camk2a-202
(1)
|
Ensembl | 881 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(camk2a:GAL4-VP16) |
|
| 1 | Torigoe et al., 2021 | |
| Tg(UAS:mCherry-2A-FLAG-cacamk2a) |
| 1 | Ogino et al., 2019 | ||
| Tg(UAS:mCherry-2A-FLAG-camk2a) |
| 1 | Ogino et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-222I18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:112538 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123320 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423709 (1) | 5545 nt | ||
| Genomic | GenBank:FO704810 (1) | 117050 nt | ||
| Polypeptide | UniProtKB:Q32PV2 (1) | 478 aa |
- Bu, H., Ding, Y., Li, J., Zhu, P., Shih, Y.H., Wang, M., Zhang, Y., Lin, X., Xu, X. (2021) Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish. JCI insight. 6(24):
- Sitaraman, S., Yadav, G., Agarwal, V., Jabeen, S., Verma, S., Jadhav, M., Thirumalai, V. (2021) Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons. eLIFE. 10:
- Torigoe, M., Islam, T., Kakinuma, H., Fung, C.C.A., Isomura, T., Shimazaki, H., Aoki, T., Fukai, T., Okamoto, H. (2021) Zebrafish capable of generating future state prediction error show improved active avoidance behavior in virtual reality. Nature communications. 12:5712
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Rothschild, S.C., Ingram, S.R., Lu, F.I., Thisse, B., Thisse, C., Parkerson, J.A., Tombes, R.M. (2020) Genetic compensation of γ CaMKII, an evolutionarily conserved gene. Gene. 742:144567
- Wang, D., Zhang, Y., Li, J., Dahlgren, R.A., Wang, X., Huang, H., Wang, H. (2020) Risk assessment of cardiotoxicity to zebrafish (Danio rerio) by environmental exposure to triclosan and its derivatives. Environmental pollution (Barking, Essex : 1987). 265:114995
- Wu, L., Chen, H., Ru, H., Li, Y., Yao, F., Ni, Z., Zhong, L. (2020) Sex-specific effects of triphenyltin chloride (TPT) on thyroid disruption and metabolizing enzymes in adult zebrafish (Danio rerio). Toxicology letters. 331:143-151
- Dragojević, J., Mihaljević, I., Popović, M., Smital, T. (2019) Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 236:110309
- Ogino, K., Yamada, K., Nishioka, T., Oda, Y., Kaibuchi, K., Hirata, H. (2019) Phosphorylation of gephyrin in zebrafish Mauthner cells governs glycine receptor clustering and behavioral desensitization to sound. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(45):8988-8997
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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