Gene

katnal2

ID

ZDB-GENE-051113-156

Name

katanin p60 subunit A-like 2

Symbol

katnal2 Nomenclature History

Previous Names

zgc:123350

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable ATP hydrolysis activity. Acts upstream of or within social behavior. Predicted to be located in microtubule and spindle pole. Predicted to be active in cytoplasm and spindle. Is expressed in brain. Used to study autism spectrum disorder. Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zheng et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Zheng et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With katnal2 Human Ortholog

No data available

Associated With katnal2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	katnal2^{zf3701/zf3701}	standard conditions	Zheng et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR006594	LIS1 homology motif
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR027497	Katanin p60 ATPase-containing subunit A-like 2
Family	IPR050304	Microtubule-severing AAA ATPase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase