Gene

comta

ID

ZDB-GENE-050913-117

Name

catechol-O-methyltransferase a

Symbol

comta Nomenclature History

Previous Names

zgc:114157 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Exhibits catechol O-methyltransferase activity. Involved in methylation. Predicted to localize to extracellular region and integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; bulimia nervosa; cognitive disorder (multiple); eumycotic mycetoma; and reproductive organ cancer (multiple). Is expressed in several structures, including digestive system; male organism; nervous system; pleuroperitoneal region; and unfertilized egg. Orthologous to human COMT (catechol-O-methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With comta Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
panic disorder	Alliance	{Panic disorder, susceptibility to}	167870
schizophrenia	Alliance	{Schizophrenia, susceptibility to}	181500

Associated With comta Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002935	Class I-like SAM-dependent O-methyltransferase
Family	IPR017128	Catechol O-methyltransferase, eukaryotic
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily