Gene
lats1
- ID
- ZDB-GENE-050523-2
- Name
- large tumor suppressor kinase 1
- Symbol
- lats1 Nomenclature History
- Previous Names
-
- si:dkey-181i3.5
- wu:fc19a11
- zgc:123219
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of with a negative effect on BMP signaling pathway. Acts upstream of or within convergent extension involved in gastrulation and secondary heart field specification. Predicted to be located in centrosome. Is expressed in several structures, including head; heart; liver; pectoral fin; and pleuroperitoneal region. Used to study autosomal dominant polycystic kidney disease. Orthologous to human LATS1 (large tumor suppressor kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chen et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Chen et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autosomal dominant polycystic kidney disease | lats1zf2211/zf2211 | standard conditions | Xu et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR049761 | Serine/threonine-protein kinase , Mob-binding domain |
| Family | IPR050236 | Serine/threonine-protein kinases, AGC |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase , Mob-binding domain | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9JTE1 | InterPro | 632 | |||||||
| UniProtKB:Q58FB8 | InterPro | 1068 | |||||||
| UniProtKB:Q5RIL6 | InterPro | 1068 |
Interactions and Pathways
No data available
Plasmids
No data available