Gene

nefma

ID

ZDB-GENE-050522-205

Name

neurofilament medium chain a

Symbol

nefma Nomenclature History

Previous Names

zgc:112359 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in neurofilament bundle assembly. Predicted to be located in neurofilament. Predicted to be active in axon; cytoplasm; and intermediate filament cytoskeleton. Is expressed in basal plate midbrain region and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112359 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nefma Human Ortholog

No data available

Associated With nefma Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018039	Intermediate filament protein, conserved site
Domain	IPR006821	Intermediate filament head, DNA-binding domain
Domain	IPR011098	G5 domain
Domain	IPR039008	Intermediate filament, rod domain
Family	IPR002957	Keratin, type I
Family	IPR050405	Intermediate filament structural protein