Gene
abcc1
- ID
- ZDB-GENE-050517-15
- Name
- ATP binding cassette subfamily C member 1 (ABCC1 blood group)
- Symbol
- abcc1 Nomenclature History
- Previous Names
-
- mrp1 (1)
- si:dkeyp-72e1.5
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable ABC-type xenobiotic transporter activity and glutathione transmembrane transporter activity. Acts upstream of or within detoxification of cadmium ion. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 77 and chronic obstructive pulmonary disease. Orthologous to human ABCC1 (ATP binding cassette subfamily C member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 77 | Alliance | ?Deafness, autosomal dominant 77 | 618915 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR005292 | Multi drug resistance-associated protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | Multi drug resistance-associated protein | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IC81
|
1518 |
Interactions and Pathways
No data available
Plasmids
No data available