Gene

kcnj1a.6

ID
ZDB-GENE-050420-272
Name
potassium inwardly rectifying channel subfamily J member 1a, tandem duplicate 6
Symbol
kcnj1a.6 Nomenclature History
Previous Names
  • si:ch211-241l24.7
  • si:ch211-244h7.8
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable ATP-activated inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa10378Allele with one point mutationUnknownPremature StopENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-kcnj1a.6
    		 (2)
    CRISPR2-kcnj1a.6
      		 (2)
      CRISPR3-kcnj1a.6
        		 (2)
        CRISPR4-kcnj1a.6
          		 (2)
          CRISPR5-kcnj1a.6
            		 (2)
            CRISPR6-kcnj1a.6
              		 (2)
              CRISPR7-kcnj1a.6
                		 (2)
                CRISPR8-kcnj1a.6
                  		 (2)
                  CRISPR9-kcnj1a.6
                    		 (2)
                    1 - 9 of 9
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                    Human Disease
                    Associated With kcnj1a.6 Human Ortholog
                    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
                    Bartter disease type 2 Alliance Bartter syndrome, type 2 241200
                    1 - 1 of 1
                    Associated With kcnj1a.6 Via Experimental Models
                    No data available
                    Gene Ontology
                    Protein Domains
                    Domain, Family, and Site Summary
                    Type InterPro ID Name
                    Domain IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
                    Domain IPR041647 Inward rectifier potassium channel, C-terminal
                    Family IPR003268 FPotassium channel, inwardly rectifying, Kir1.1
                    Family IPR016449 Potassium channel, inwardly rectifying, Kir
                    Homologous_superfamily IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
                    1 - 5 of 6 Show all
                    Domain Details Per Protein
                    Protein Length FPotassium channel, inwardly rectifying, Kir1.1 Immunoglobulin E-set Inward rectifier potassium channel, C-terminal Potassium channel, inwardly rectifying, Kir Potassium channel, inwardly rectifying, Kir, cytoplasmic Potassium channel, inwardly rectifying, transmembrane domain
                    UniProtKB:Q1LUW7
                    InterPro
                    		370
                    UniProtKB:Q1L8I9
                    InterPro
                    		370
                    1 - 2 of 2
                    Transcripts
                    Genome Browsers
                    Genome Build: GRCz11Chromosome: 18
                    Type Name Annotation Method Has Havana Data Length (nt) Analysis
                    mRNA kcnj1a.6-201 (1)
                    Ensembl
                    		Ensembl 1,792 nt
                    ZFIN BLAST
                    mRNA kcnj1a.6-202 (1)
                    Ensembl
                    		Ensembl 1,826 nt
                    ZFIN BLAST
                    1 - 2 of 2
                    Interactions and Pathways
                    No data available
                    Antibodies
                    No data available
                    Plasmids
                    No data available
                    Constructs
                    No data available
                    Marker Relationships
                    Relationship Marker Type Marker Accession Numbers Citations
                    Contained inBACCH211-244H7ZFIN Curated Data
                    1 - 1 of 1
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                    Sequences
                    Type Accession # Sequence Length (nt/aa) Analysis
                    RNARefSeq:NM_001045175 (1)1793 nt
                    ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
                    GenomicGenBank:BX927076 (1)152951 nt
                    MegaBLASTEnsembl
                    PolypeptideUniProtKB:Q1L8I9 (1)370 aa
                    ZFIN BLASTSIB BLASTEnsembl Protein Blast
                    Orthology
                    Comparative Orthology
                    Alliance
                    Gene Tree
                    Ensembl
                    Species Symbol Chromosome Accession # Evidence
                    HumanKCNJ111
                    Phylogenetic tree (1)
                    Conserved genome location (synteny) (2)
                    Amino acid sequence comparison (1)
                    MouseKcnj19
                    Phylogenetic tree (1)
                    Amino acid sequence comparison (1)
                    Conserved genome location (synteny) (2)
                    Citations
                    TSV
                    1 - 3 of 3
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