Gene

alx1

ID

ZDB-GENE-050419-191

Name

ALX homeobox 1

Symbol

alx1 Nomenclature History

Previous Names

si:ch211-154h20.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in embryonic cranial skeleton morphogenesis and neural crest cell migration. Predicted to localize to nucleus. Is expressed in head; head mesenchyme; neural crest; pectoral fin bud; and presumptive cephalic mesoderm. Orthologous to human ALX1 (ALX homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alx1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
frontonasal dysplasia 3	Alliance	Frontonasal dysplasia 3	613456

Associated With alx1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
frontonasal dysplasia 3	alx1^{uw2016/uw2016} (NHGRI-1)	standard conditions	Pini et al., 2020
frontonasal dysplasia 3	WT + MO1-alx1	standard conditions	Dee et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR003654	OAR domain
Family	IPR050649	Paired Homeobox Transcription Factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily