Gene
rasgrp4
- ID
- ZDB-GENE-050419-110
- Name
- RAS guanyl releasing protein 4
- Symbol
- rasgrp4 Nomenclature History
- Previous Names
-
- si:dkey-12o15.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity and guanyl-nucleotide exchange factor activity. Involved in lymph vessel development. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in caudal vein plexus; dorsal aorta; head; notochord; and posterior cardinal vein. Orthologous to several human genes including RASGRP4 (RAS guanyl releasing protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Huang et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Huang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
Domain | IPR000651 | Ras-like guanine nucleotide exchange factor, N-terminal |
Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
Domain | IPR002048 | EF-hand domain |
Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
Family | IPR008937 | Ras-like guanine nucleotide exchange factor |
Homologous_superfamily | IPR011992 | EF-hand domain pair |
Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
Protein | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor | Ras-like guanine nucleotide exchange factor, N-terminal |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q1L9A0
|
687 | |||||||||||
UniProtKB:A0A8M2BKX7
|
693 | |||||||||||
UniProtKB:A0A8M9PM49
|
692 | |||||||||||
UniProtKB:A0A8M2BKX1
|
720 | |||||||||||
UniProtKB:A0A8M2BLA4
|
725 | |||||||||||
UniProtKB:A0A8M3AJR7
|
724 | |||||||||||
UniProtKB:A0A8M2BKY0
|
695 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
rasgrp4-201
(1)
|
Ensembl | 3434 nt | |
mRNA |
rasgrp4-202
(1)
|
Havana | 3443 nt |
Interactions and Pathways
No data available
Plasmids
No data available