Gene
arhgap1
- ID
- ZDB-GENE-050417-305
- Name
- Rho GTPase activating protein 1
- Symbol
- arhgap1 Nomenclature History
- Previous Names
-
- fk03b12
- fk61c06
- wu:cegs2891
- wu:fk03b12
- wu:fk61c06
- zgc:110361
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endocytic recycling and small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Is expressed in female organism; musculature system; nervous system; and somite. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110361 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-arhgap1 | Thyme et al., 2019 | |
| CRISPR2-arhgap1 | Thyme et al., 2019 | |
| CRISPR3-arhgap1 | Thyme et al., 2019 | |
| CRISPR4-arhgap1 | Thyme et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR049592 | Rho GTPase-activating protein 1, RhoGAP domain |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | Rho GTPase-activating protein 1, RhoGAP domain | Rho GTPase-activating protein domain | Rho GTPase activation protein |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q568D8 | InterPro | 434 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgap1-201
(1)
|
Ensembl | 3,653 nt | ||
| mRNA |
arhgap1-203
(1)
|
Ensembl | 1,306 nt | ||
| ncRNA |
arhgap1-002
(1)
|
Ensembl | 440 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-23N7 | ZFIN Curated Data | |
| Encodes | EST | cegs2891 | Rauch et al., 2003 | |
| Encodes | EST | fk03b12 | ||
| Encodes | EST | fk61c06 | ||
| Encodes | EST | fr86c05 | ||
| Encodes | cDNA | MGC:110361 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191702 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017781 (1) | 1500 nt | ||
| Genomic | GenBank:BX957256 (1) | 227909 nt | ||
| Polypeptide | UniProtKB:Q568D8 (1) | 434 aa |
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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