Gene
trim2a
- ID
- ZDB-GENE-050327-99
- Name
- tripartite motif containing 2a
- Symbol
- trim2a Nomenclature History
- Previous Names
-
- trim2 (1)
- zgc:113099
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable translation repressor activity and ubiquitin protein ligase activity. Acts upstream of or within myeloid cell differentiation and primitive hemopoiesis. Predicted to be located in cytoplasm. Is expressed in blood cell and vascular endothelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cannon et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Cannon et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 2R | Alliance | Charcot-Marie-Tooth disease, type 2R | 615490 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR000315 | B-box-type zinc finger |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR003649 | B-box, C-terminal |
| Domain | IPR027370 | Zinc finger, RING-type, eukaryotic |
| Family | IPR050952 | Tripartite Motif and NHL Repeat Containing E3 Ligases |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Repeat | IPR001258 | NHL repeat |
| Repeat | IPR001298 | Filamin/ABP280 repeat |
| Repeat | IPR017868 | Filamin/ABP280 repeat-like |
Domain Details Per Protein
| Protein | Length | B-box, C-terminal | B-box-type zinc finger | Filamin/ABP280 repeat | Filamin/ABP280 repeat-like | Immunoglobulin E-set | Immunoglobulin-like fold | NHL repeat | Six-bladed beta-propeller, TolB-like | Tripartite Motif and NHL Repeat Containing E3 Ligases | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, RING-type, eukaryotic |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BIL2
|
520 | |||||||||||||
|
UniProtKB:Q58ER5
|
744 | |||||||||||||
|
UniProtKB:F1QFW2
|
744 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trim2a-201
(1)
|
Ensembl | 3,089 nt |
Interactions and Pathways
No data available
Plasmids
No data available