Gene
parla
- ID
- ZDB-GENE-050327-8
- Name
- presenilin associated, rhomboid-like a
- Symbol
- parla Nomenclature History
- Previous Names
-
- parlb (2)
- zgc:112986
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to act upstream of or within proteolysis. Predicted to be located in mitochondrial inner membrane. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112986 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Noble et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Peptidase S54, rhomboid domain | Rhomboid-like superfamily | Rhomboid protease S54 |
|---|---|---|---|---|
|
UniProtKB:A0A8M3AN93
|
195 | |||
|
UniProtKB:A0A8M9PWK1
|
318 | |||
|
UniProtKB:B2GQL1
|
383 | |||
|
UniProtKB:A0A8M3AN88
|
280 | |||
|
UniProtKB:Q58EK4
|
383 |
Interactions and Pathways
No data available
Plasmids
No data available