dnmt3aa

ID

ZDB-GENE-050314-5

Name

DNA (cytosine-5-)-methyltransferase 3 alpha a

Symbol

dnmt3aa Nomenclature History

Previous Names

dnmt3a2 (1)
dnmt8

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates; DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates; and metal ion binding activity. Acts upstream of or within regulation of ATP citrate synthase activity; response to temperature stimulus; and swimming behavior. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; nervous system; pleuroperitoneal region; spinal cord neural tube; and swim bladder bud. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnmt3aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Acute myeloid leukemia, somatic	601626
Tatton-Brown-Rahman syndrome	Alliance	Tatton-Brown-Rahman syndrome	615879
		Heyn-Sproul-Jackson syndrome	618724

Associated With dnmt3aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018117	DNA methylase, C-5 cytosine-specific, active site
Domain	IPR000313	PWWP domain
Domain	IPR025766	ADD domain
Domain	IPR040552	DNMT3, cysteine rich ADD domain, GATA1-like zinc finger
Domain	IPR044108	DNA (cytosine-5)-methyltransferase 3A, ADD domain
Domain	IPR049554	DNMT3, ADD domain, PHD zinc finger
Domain	IPR054724	DNA (cytosine-5)-methyltransferase, N-terminal
Family	IPR001525	C-5 cytosine methyltransferase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily