ZFIN ID: ZDB-GENE-050302-80

Gene Name:signal peptide, CUB domain, EGF-like 2
Gene Symbol: scube2

Previous Names: u-shaped somites(1) , you, wu:fc27f08, U shaped somites
Nomenclature History

---

GENE EXPRESSION:(current status)

All expression data:	6 figure(s) from 5 publications
Wild Type Stages, Structures:	Zygote:1-cell (0.00h-0.75h) to Hatching:Long-pec (48.00h-60.00h)
	brain, central nervous system ... (all 22)
Curated microarray expression:	GEO  (1)

---

MUTANTS AND TARGETED KNOCKDOWNS:

Mutant line(s):   7 genotypes
Allele(s):   rw87, tm146c, ty97, tz310b

Phenotype: (current status)

Data:	5 figures from 2 publications
Observed in:	floor plate, melanocyte, muscle cell development, myoseptum, notochord ... (all 7)

Knockdown reagents: MO1-scube2 (1) ,   MO2-scube2 (1)

---

GENE PRODUCTS:

Gene Ontology

Ontology	GO Term
Biological Process	negative regulation of BMP signaling pathway (more)
Cellular Component	cell surface (more)
Molecular Function	calcium ion binding

All GO Terms (13)

Protein Families, Domains and Sites:

InterPro:IPR000152 (1) InterPro:IPR000742 (1) InterPro:IPR000859 (1) InterPro:IPR001881 (1) InterPro:IPR006210 (1) InterPro:IPR009030 (1) InterPro:IPR011641 (1) InterPro:IPR013032 (1) InterPro:IPR013091 (1) InterPro:IPR018097 (1)

PROSITE:PS00010 (1) PROSITE:PS00022 (1) PROSITE:PS01180 (1) PROSITE:PS01186 (1) PROSITE:PS01187 (1) PROSITE:PS50026 (1)

Pfam:PF00431 (1) Pfam:PF07645 (1) Pfam:PF07699 (1)

Gene Product Description

---

SEGMENT (CLONE AND PROBE) RELATIONSHIPS:

scube2 Encodes

[EST] fc27f08 [cDNA] AY741664    (order this)

---

SEQUENCE INFORMATION:

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001014813 (1)	3989 bp	- Select Tool - ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AP007256 (1)	155274 bp	- Select Tool - MegaBLAST Ensembl
Polypeptide	UniProtKB:Q5G872 (1)	1010 aa	- Select Tool - ZFIN BLAST Ensembl SIB BLAST
Sequence Clusters	UniGene:150435 (1)
All Sequence Information (12)

---

OTHER  scube2  GENE / MARKER PAGES:

Entrez Gene:503728 (1)

Ensembl(Zv8):ENSDARG00000037362 (1)

---

MAPPING INFORMATION:

LG:  7    Details

---

ORTHOLOGY:

				Evidence
Species	Symbol	Chromosome (Position)	Accession #	AA	CL
Zebrafish	scube2	7
Human	SCUBE2	11 (p15.3)	Entrez Gene:57758
Mouse	Scube2	7 (50.00 cM)	MGI:1928765 Entrez Gene:56788
Orthology Details

---

CITATIONS   (26)