ZFIN is now using GRCz12tu for Genomic Data

Gene

dyrk1aa

ID

ZDB-GENE-050302-29

Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a

Symbol

dyrk1aa Nomenclature History

Previous Names

dyrk1a
im:6962097
zgc:158359

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within angiogenesis and brain development. Predicted to be active in nucleus. Is expressed in several structures, including brain; endothelial cell; eye; heart; and spinal cord. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dyrk1aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 7	Alliance	Intellectual developmental disorder, autosomal dominant 7	614104

Associated With dyrk1aa Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	dyrk1aa^krb1/krb1	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR044131	Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain
Family	IPR050494	Serine/threonine and dual-specificity kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine and dual-specificity kinase	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M1P9M8	InterPro	733
UniProtKB:A1L1U2	InterPro	737

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dyrk1aa-201 (1) Ensembl	Ensembl	2,214 nt	Select Tool ZFIN BLAST
mRNA	dyrk1aa-203 (1) Ensembl	Ensembl	695 nt	Select Tool ZFIN BLAST
mRNA	dyrk1aa-204 (1) Ensembl	Ensembl	1,216 nt	Select Tool ZFIN BLAST
mRNA	dyrk1aa-206 (1) Ensembl	Ensembl	3,573 nt	Select Tool ZFIN BLAST
ncRNA	dyrk1aa-003 (1) Ensembl	Ensembl	424 nt	Select Tool ZFIN BLAST
ncRNA	dyrk1aa-004 (1) Ensembl	Ensembl	574 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations