Gene
nfia
- ID
- ZDB-GENE-050208-501
- Name
- nuclear factor I/A
- Symbol
- nfia Nomenclature History
- Previous Names
-
- si:ch211-88d2.2
- wu:fq27e07
- zgc:158351
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within axon development. Predicted to be active in nucleus. Is expressed in brain. Human ortholog(s) of this gene implicated in NFIA-related disorder. Orthologous to human NFIA (nuclear factor I A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| NFIA-related disorder | Alliance | Brain malformations with or without urinary tract defects | 613735 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019739 | CTF transcription factor/nuclear factor 1, conserved site |
| Domain | IPR003619 | MAD homology 1, Dwarfin-type |
| Domain | IPR019548 | CTF transcription factor/nuclear factor 1, N-terminal |
| Domain | IPR020604 | CTF transcription factor/nuclear factor 1, DNA-binding domain |
| Family | IPR000647 | CTF transcription factor/nuclear factor 1 |
Domain Details Per Protein
| Protein | Additional Resources | Length | CTF transcription factor/nuclear factor 1 | CTF transcription factor/nuclear factor 1, conserved site | CTF transcription factor/nuclear factor 1, DNA-binding domain | CTF transcription factor/nuclear factor 1, N-terminal | MAD homology 1, Dwarfin-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B5H7 | InterPro | 527 | |||||
| UniProtKB:A1A5X3 | InterPro | 481 | |||||
| UniProtKB:A0A8M3AM79 | InterPro | 570 | |||||
| UniProtKB:A0A8M3AUN3 | InterPro | 587 | |||||
| UniProtKB:A0A8M3AUN8 | InterPro | 564 | |||||
| UniProtKB:A0A8M3AM86 | InterPro | 544 | |||||
| UniProtKB:A0A8M3AMZ3 | InterPro | 567 | |||||
| UniProtKB:A0A8M3AXN2 | InterPro | 567 |
Interactions and Pathways
No data available
Plasmids
No data available