ZFIN is now using GRCz12tu for Genomic Data
Gene
alx4b
- ID
- ZDB-GENE-050208-140
- Name
- ALX homeobox 4b
- Symbol
- alx4b Nomenclature History
- Previous Names
-
- im:7142878
- si:ch73-220n21.1
- zgc:162606 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in animal organ development and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; eye; optic vesicle; pharyngeal arch; and swim bladder bud. Human ortholog(s) of this gene implicated in several diseases, including craniosynostosis; frontonasal dysplasia 2; gastrointestinal system cancer (multiple); lung cancer (multiple); and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142878 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontonasal dysplasia 2 | Alliance | Frontonasal dysplasia 2 | 613451 |
| parietal foramina | Alliance | Parietal foramina 2 | 609597 |
| {Craniosynostosis 5, susceptibility to} | 615529 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003654 | OAR domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | OAR domain |
|---|---|---|---|
| UniProtKB:A0A2R8RTN2 | InterPro | 259 | |
| UniProtKB:A0AC58HT46 | InterPro | 364 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers