Gene

alg12

ID

ZDB-GENE-041210-295

Name

ALG12 alpha-1,6-mannosyltransferase

Symbol

alg12 Nomenclature History

Previous Names

si:dkey-164m14.3 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have alpha-1,6-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ig. Orthologous to human ALG12 (ALG12 alpha-1,6-mannosyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa45179	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With alg12 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital disorder of glycosylation Ig	Alliance	Congenital disorder of glycosylation, type Ig	607143

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Associated With alg12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR005599	GPI mannosyltransferase

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Domain Details Per Protein

Protein	Length	GPI mannosyltransferase
UniProtKB:A5PLJ6 InterPro	493

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 4

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	alg12-201 (1) Ensembl	Ensembl	1,867 nt	Select Tool ZFIN BLAST
ncRNA	alg12-002 (1) Ensembl	Ensembl	820 nt	Select Tool ZFIN BLAST
ncRNA	alg12-003 (1) Ensembl	Ensembl	680 nt	Select Tool ZFIN BLAST
ncRNA	alg12-004 (1) Ensembl	Ensembl	845 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-164M14	CR751234	ZFIN Curated Data
Encodes	cDNA	MGC:165660	BC142932	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001098749 (1)	1586 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR751234 (1)	218596 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A5PLJ6 (1)	493 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	ALG12	22	Ensembl:ENSG00000182858 Gene:79087 OMIM:607144 HGNC:19358	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Alg12	15	Ensembl:ENSMUSG00000035845 MGI:2385025 Gene:223774	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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