Gene
foxp1b
- ID
- ZDB-GENE-041203-1
- Name
- forkhead box P1b
- Symbol
- foxp1b Nomenclature History
- Previous Names
-
- foxp1 (1)
- im:7139058
- wu:fc83a06
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including gut; hatching gland; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; congenital heart disease; esophagus adenocarcinoma; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139058 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010941Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015928Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025595Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029234Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nub89 | Allele with one deletion | Exon 14 | Unknown | CRISPR | |
| sa16567 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20798 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40774 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxp1b | (2) | |
| CRISPR2-foxp1b | Itoh et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| intellectual disability-severe speech delay-mild dysmorphism syndrome | Alliance | Intellectual developmental disorder with language impairment with or without autistic features | 613670 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein P | Forkhead box protein P1/P2, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXP, coiled-coil domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PM82 | InterPro | 675 | |||||||
| UniProtKB:Q2LE08 | InterPro | 659 | |||||||
| UniProtKB:A0A8M9Q673 | InterPro | 676 | |||||||
| UniProtKB:A0A8M9PZW2 | InterPro | 660 | |||||||
| UniProtKB:A0A8M3ATJ4 | InterPro | 535 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxp1b-201
(1)
|
Ensembl | 2,428 nt | ||
| mRNA |
foxp1b-202
(1)
|
Ensembl | 2,338 nt | ||
| mRNA |
foxp1b-205
(1)
|
Ensembl | 486 nt | ||
| mRNA |
foxp1b-208
(1)
|
Ensembl | 923 nt | ||
| mRNA |
foxp1b-209
(1)
|
Ensembl | 2,046 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-143A8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-58F6 | ||
| Contained in | BAC | DKEY-160M3 | ZFIN Curated Data | |
| Encodes | EST | fc83a06 | ||
| Encodes | EST | IMAGE:7139058 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:194951 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039637 (1) | 2440 nt | ||
| Genomic | GenBank:BX957311 (2) | 222994 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q673 (1) | 676 aa |
- Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., Hibi, M. (2024) Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 151(7):
- Lattanzi, R., Fullone, M.R., De Biase, A., Maftei, D., Vincenzi, M., Miele, R. (2024) Biochemical characterization of Prokineticin 2 binding to Prokineticin receptor 1 in zebrafish. Neuropeptides. 107:102456102456
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Lüffe, T.M., D'Orazio, A., Bauer, M., Gioga, Z., Schoeffler, V., Lesch, K.P., Romanos, M., Drepper, C., Lillesaar, C. (2021) Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders. Translational psychiatry. 11:529
- Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
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