Research
General Information
ZIRC
ZFIN: Gene: ext2
ZFIN ID: ZDB-GENE-041124-3

Gene Name:exostoses (multiple) 2
Gene Symbol: ext2
Previous Names: wu:fc14g07(1) , dak, dackel, fc14g07, ext2a(1)
Nomenclature History


GENE EXPRESSION:(current status)
All expression data: 1 figure(s) from Lee et al., 2004
Wild Type Stages, Structures: Cleavage:4-cell (1.00h-1.25h) to Pharyngula:Prim-25 (36.00h-42.00h)
  nervous system, pectoral fin musculature, whole organism
Curated microarray expression: GEO  (1)

MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   4 genotypes
Allele(s):   tf205, to273b, to79c, tw25e
Phenotype: (current status)
  Data: 15 figures from 4 publications
  Observed in: cartilage, cartilage development, ceratobranchial 4 cartilage, chondrocyte, fin ... (all 21)

GENE PRODUCTS:

Gene Ontology
Ontology GO Term
Biological Process cartilage development (more)
Cellular Component intrinsic to endoplasmic reticulum membrane (more)
Molecular Function N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity (more)
All GO Terms (14)

Protein Families, Domains and Sites:
  • InterPro:IPR004263 (1)
  • InterPro:IPR015338 (1)
  • Pfam:PF03016 (1)
  • Pfam:PF09258 (1)
  • Loading Transcript Data...

    SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
    ext2 Contained in [BAC] CH211-107P11 (1)    (order this)
    ext2 Encodes [EST] fc14g07

    SEQUENCE INFORMATION:
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001008400 (1) 3195 bp
    Genomic GenBank:BX510305 (1) 156938 bp
    Polypeptide UniProtKB:Q5U7A7 (1) 719 aa
    Sequence Clusters UniGene:37595 (1)
    All Sequence Information (8)

    OTHER  ext2  GENE / MARKER PAGES:

  • Entrez Gene:493780 (1)
  • VEGA:OTTDARG00000020136 (1)
  • Ensembl(Zv8):ENSDARG00000056648 (1)

  • MAPPING INFORMATION:
      LG:  7    Details   View Map: Merged  Individual Panels

    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish ext2  7
    Human EXT2  11 (p12-p11)
  • OMIM:608210
  • Entrez Gene:2132
  • Mouse Ext2  2 (51.62 cM)
  • MGI:108050
  • Entrez Gene:14043
  • Orthology Details

    CITATIONS   (29)