Gene

arhgef39

ID

ZDB-GENE-041114-28

Name

Rho guanine nucleotide exchange factor (GEF) 39

Symbol

arhgef39 Nomenclature History

Previous Names

zgc:103517

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of cell migration. Predicted to be active in plasma membrane. Orthologous to human ARHGEF39 (Rho guanine nucleotide exchange factor 39).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103517 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa9083	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa33420	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With arhgef39 Human Ortholog

No data available

Associated With arhgef39 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Family	IPR042987	Rho guanine nucleotide exchange factor 39
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily

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Domain Details Per Protein

Protein	Additional Resources	Length	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	Rho guanine nucleotide exchange factor 39
UniProtKB:B0R089	InterPro	427
UniProtKB:F1QG07	InterPro	426

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 4

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	arhgef39-203 (1) Ensembl	Ensembl	961 nt	Select Tool ZFIN BLAST
mRNA	arhgef39-201 (1) Ensembl	Ensembl	1,981 nt	Select Tool ZFIN BLAST
mRNA	arhgef39-202 (1) Ensembl	Ensembl	2,542 nt	Select Tool ZFIN BLAST
mRNA	arhgef39-204 (1) Ensembl	Ensembl	1,589 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-8M7	AL844512	ZFIN Curated Data
Encodes	cDNA	MGC:103517	BC085538	ZFIN Curated Data
Encodes	cDNA	MGC:173755	BC152152	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001007341 (1)	1983 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL844512 (2)	231383 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:B0R089 (1)	427 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	ARHGEF39	9	Ensembl:ENSG00000137135 Gene:84904 HGNC:25909	Amino acid sequence comparison (1)
Mouse	Arhgef39	4	Ensembl:ENSMUSG00000051517 Gene:230098 MGI:3036286	Amino acid sequence comparison (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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