Gene

mvda

ID

ZDB-GENE-041114-127

Name

mevalonate (diphospho) decarboxylase a

Symbol

mvda Nomenclature History

Previous Names

zgc:100824 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have diphosphomevalonate decarboxylase activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:100824 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Wong et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mvda Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Porokeratosis 7, multiple types	614714

Associated With mvda Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006204	GHMP kinase N-terminal domain
Domain	IPR041431	Mvd1, C-terminal
Family	IPR005935	Diphosphomevalonate/phosphomevalonate decarboxylase
Family	IPR029765	Diphosphomevalonate decarboxylase
Homologous_superfamily	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR036554	GHMP kinase, C-terminal domain superfamily