Research
General Information
ZIRC
ZFIN: Gene: cep290
ZFIN ID: ZDB-GENE-041111-243

Gene Name:centrosomal protein 290
Gene Symbol: cep290
Previous Names: nephrocystin-6(1) , im:7145703, nphp6(1) , im:7147820(1)
Nomenclature History


GENE EXPRESSION:(current status)
All expression data: 3 figure(s) from 2 publications
Directly submitted expression data: 1 figure(s) (1 images) from Thisse et al., 2004 [IMAGE:7147820]
  1 figure(s) (1 images) from Thisse et al., 2004 [IMAGE:7145703]
Wild Type Stages, Structures: Zygote:1-cell (0.00h-0.75h) to Hatching:Pec-fin (60.00h-72.00h)
  central nervous system, cerebellum ... (all 5)
Curated microarray expression: GEO  (1)

MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   2 genotypes
Allele(s):   fh297, unrec_cep290
Phenotype: (current status)
  Data: 5 figures from 3 publications
  Observed in: brain, cerebellum development, cerebellum structural organization, cloacal septation, eye ... (all 15)
Knockdown reagents: MO1-cep290 (1) ,   MO2-cep290 (1) ,   MO3-cep290 (1) ,   MO4-cep290 (1) ,   MO5-cep290 (1)

GENE PRODUCTS:

Gene Ontology
Ontology GO Term
Molecular Function molecular_function
Biological Process gastrulation (more)
Cellular Component cytoplasm (more)
All GO Terms (12)

Gene Product Description


SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
cep290 Contained in [BAC] CH211-244M13    (order this) , DKEY-30I6    (order this)
cep290 Encodes [EST] IMAGE:7145703 (1)    (order this) , IMAGE:7147820 (1)    (order this)

SEQUENCE INFORMATION:
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001168267 (1) 7580 bp
Genomic GenBank:BX901919 (1) 233401 bp
Polypeptide UniProtKB:P85001 (1) 2439 aa
Sequence Clusters UniGene:26022 (1)
All Sequence Information (9)

OTHER  cep290  GENE / MARKER PAGES:

  • Entrez Gene:560588 (1)
  • Ensembl(Zv8):ENSDARG00000062727 (1)

  • MAPPING INFORMATION:
      LG:  25  Details

    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish cep290  25
    Human CEP290  12 (q21.32)
  • OMIM:610142
  • Entrez Gene:80184
  • Mouse Cep290  10 (59.00 cM)
  • MGI:2384917
  • Entrez Gene:216274
  • Orthology Details

    CITATIONS   (15)