Gene

fmnl2b

ID

ZDB-GENE-041111-182

Name

formin-like 2b

Symbol

fmnl2b Nomenclature History

Previous Names

fa31c06
im:7143207
wu:fa31c06

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to localize to cytosol. Is expressed in several structures, including hatching gland; heart tube; nervous system; optic cup; and solid lens vesicle. Orthologous to human FMNL2 (formin like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7143207 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fmnl2b Human Ortholog

No data available

Associated With fmnl2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010472	Formin, FH3 domain
Domain	IPR010473	Formin, GTPase-binding domain
Domain	IPR014767	Diaphanous autoregulatory (DAD) domain
Domain	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Domain	IPR015425	Formin, FH2 domain
Family	IPR043592	Formin-like protein, animal
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR042201	Formin, FH2 domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	Diaphanous autoregulatory (DAD) domain	Formin, FH2 domain	Formin, FH2 domain superfamily	Formin, FH3 domain	Formin, GTPase-binding domain	Formin-like protein, animal	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
UniProtKB:A0A8M3B3A0 InterPro	1103
UniProtKB:A0A2R8RYU9 InterPro	1110
UniProtKB:A0A8M3AT86 InterPro	1097
UniProtKB:E7F0M4 InterPro	1104

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fmnl2b-201 (1) Ensembl	Ensembl	4,314 nt	Select Tool ZFIN BLAST
mRNA	fmnl2b-202 (1) Ensembl	Ensembl	609 nt	Select Tool
mRNA	fmnl2b-203 (1) Ensembl	Ensembl	2,913 nt	Select Tool
mRNA	fmnl2b-204 (1) Ensembl	Ensembl	4,308 nt	Select Tool ZFIN BLAST
mRNA	fmnl2b-205 (1) Ensembl	Ensembl	4,389 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations