Gene

myo5aa

ID

ZDB-GENE-041027-2

Name

myosin VAa

Symbol

myo5aa Nomenclature History

Previous Names

myo5a
si:dkey-266j9.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Orthologous to human MYO5A (myosin VA).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo5aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Griscelli syndrome type 1	Alliance	Griscelli syndrome, type 1	214450

Associated With myo5aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR002710	Dilute domain
Domain	IPR004009	Myosin, N-terminal, SH3-like
Domain	IPR036103	Class V myosin, motor domain
Domain	IPR037988	Myosin 5a, cargo-binding domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Class V myosin, motor domain	Dilute domain	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Myosin 5a, cargo-binding domain	Myosin, N-terminal, SH3-like	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M3AJS5 InterPro	1846
UniProtKB:A0A8M2BKY7 InterPro	1828
UniProtKB:A0A8M9PPP8 InterPro	1850
UniProtKB:A0A8M3B332 InterPro	1825
UniProtKB:A0A8M9PW04 InterPro	1849
UniProtKB:A0A8M2BKY1 InterPro	1827
UniProtKB:A0A8M9P1G5 InterPro	1368
UniProtKB:A0A8M9PAJ4 InterPro	1340
UniProtKB:A0A8M9PPQ8 InterPro	1854
UniProtKB:A0A8M3AV30 InterPro	1848
UniProtKB:A0A8M3AS48 InterPro	1847

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myo5aa-201 (1) Ensembl	Ensembl	5,535 nt	Select Tool ZFIN BLAST
mRNA	myo5aa-202 (1) Ensembl	Ensembl	5,535 nt	Select Tool
mRNA	myo5aa-203 (1) Ensembl	Ensembl	844 nt	Select Tool
mRNA	myo5aa-204 (1) Ensembl	Ensembl	5,735 nt	Select Tool
mRNA	myo5aa-206 (1) Ensembl	Ensembl	5,809 nt	Select Tool ZFIN BLAST
ncRNA	myo5aa-005 (1) Ensembl	Ensembl	815 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations