Gene
cdc42bpab
- ID
- ZDB-GENE-080219-17
- Name
- CDC42 binding protein kinase alpha (DMPK-like) b
- Symbol
- cdc42bpab Nomenclature History
- Previous Names
-
- fb82d10
- si:ch211-89p3.3
- wu:fb82d10
- zgc:174985
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in lamellipodium. Predicted to be active in actomyosin and cytoplasm. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8673 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13720 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23762 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37106 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37107 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37108 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | C1-like domain superfamily | Citron homology (CNH) domain | CRIB domain | KELK-motif containing domain | Myotonic dystrophy protein kinase, coiled coil | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Rho-associated Serine/Threonine Kinase | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase MRCK alpha, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PSV8
|
1787 | ||||||||||||||||
|
UniProtKB:A0A8M9PPH2
|
1800 | ||||||||||||||||
|
UniProtKB:A0A8M9PPH6
|
1775 | ||||||||||||||||
|
UniProtKB:A0A8M9P2P6
|
1799 | ||||||||||||||||
|
UniProtKB:A0A8M2B7M9
|
1768 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdc42bpab-201
(1)
|
Ensembl | 8,191 nt | ||
| mRNA |
cdc42bpab-202
(1)
|
Ensembl | 1,949 nt | ||
| ncRNA |
cdc42bpab-002
(1)
|
Ensembl | 540 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-89P3 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-8F4 | ZFIN Curated Data | |
| Encodes | EST | fb82d10 | ||
| Encodes | cDNA | MGC:174985 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045094 (1) | 5555 nt | ||
| Genomic | GenBank:BX470255 (1) | 203708 nt | ||
| Polypeptide | UniProtKB:A0A8M9PPH2 (1) | 1800 aa |
- Comparative Orthology
- Alliance
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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