Gene

prg4b

ID

ZDB-GENE-041014-324

Name

proteoglycan 4b

Symbol

prg4b Nomenclature History

Previous Names

prg4
si:dkey-97o5.3
zgc:122988

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity; polysaccharide binding activity; and scavenger receptor activity. Predicted to be involved in immune response. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Askary et al., 2016

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prg4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
camptodactyly-arthropathy-coxa vara-pericarditis syndrome	Alliance	Camptodactyly-arthropathy-coxa vara-pericarditis syndrome	208250

Associated With prg4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018486	Hemopexin, conserved site
Domain	IPR000585	Hemopexin-like domain
Domain	IPR001212	Somatomedin B domain
Domain	IPR020436	Somatomedin B domain, chordata
Family	IPR051298	Heme transport and cell adhesion protein
Homologous_superfamily	IPR036024	Somatomedin B-like domain superfamily
Homologous_superfamily	IPR036375	Hemopexin-like domain superfamily
Repeat	IPR018487	Hemopexin-like repeats