Gene
igf2r
- ID
- ZDB-GENE-041014-300
- Name
- insulin-like growth factor 2 receptor
- Symbol
- igf2r Nomenclature History
- Previous Names
-
- CI-MPR (1)
- si:ch211-214g8.2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have insulin-like growth factor binding activity. Predicted to be involved in lysosomal transport. Predicted to localize to late endosome; plasma membrane; and trans-Golgi network. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Is expressed in nervous system; presumptive neural retina; and somite. Orthologous to human IGF2R (insulin like growth factor 2 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000562 | Fibronectin type II domain |
Domain | IPR044865 | MRH domain |
Homologous_superfamily | IPR009011 | Mannose-6-phosphate receptor binding domain superfamily |
Homologous_superfamily | IPR013806 | Kringle-like fold |
Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
Repeat | IPR000479 | Cation-independent mannose-6-phosphate receptor repeat |
Domain Details Per Protein
Protein | Length | Cation-independent mannose-6-phosphate receptor repeat | Fibronectin type II domain | Fibronectin type II domain superfamily | Kringle-like fold | Mannose-6-phosphate receptor binding domain superfamily | MRH domain |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PSQ1
|
2408 | ||||||
UniProtKB:Q2TTK0
|
2459 |
Interactions and Pathways
No data available
Plasmids
No data available