Gene

ercc8

ID

ZDB-GENE-041010-60

Name

excision repair cross-complementation group 8

Symbol

ercc8 Nomenclature History

Previous Names

CSA (1)
zgc:103550

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in cellular protein metabolic process; positive regulation of DNA repair; and transcription-coupled nucleotide-excision repair. Predicted to localize to Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Human ortholog(s) of this gene implicated in Cockayne syndrome and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:103550 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ercc8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cockayne syndrome A	Alliance	Cockayne syndrome, type A	216400
UV-sensitive syndrome	Alliance	UV-sensitive syndrome 2	614621

Associated With ercc8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Family	IPR042238	DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat

Domain Details Per Protein

Protein	Length	DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1	G-protein beta WD-40 repeat	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q5XJ81 InterPro	400

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ercc8-201 (1) Ensembl	Havana	1863 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ercc8-203 (1) Ensembl	Havana	783 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ercc8-003 (1) Ensembl	Havana	990 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ercc8-004 (1) Ensembl	Havana	437 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations