Gene
tars1
- ID
- ZDB-GENE-041010-218
- Name
- threonyl-tRNA synthetase 1
- Symbol
- tars1 Nomenclature History
- Previous Names
-
- tars
- wu:fb07c05
- wu:fb39c12
- zgc:92586 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have threonine-tRNA ligase activity. Involved in branching involved in blood vessel morphogenesis and regulation of sprouting angiogenesis. Predicted to localize to cytoplasm. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; optic vesicle; and segmental plate. Orthologous to human TARS1 (threonyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92586 (1 image)
- IMAGE:7136667 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonphotosensitive trichothiodystrophy 7 | Alliance | Trichothiodystrophy 7, nonphotosensitive | 618546 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
| Domain | IPR004095 | TGS |
| Domain | IPR004154 | Anticodon-binding |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR012947 | Threonyl/alanyl tRNA synthetase, SAD |
| Domain | IPR033728 | Threonine-tRNA ligase catalytic core domain |
| Domain | IPR047246 | Threonine-tRNA ligase, class IIa, anticodon-binding domain |
| Family | IPR002320 | Threonine-tRNA ligase, class IIa |
| Homologous_superfamily | IPR012675 | Beta-grasp domain superfamily |
| Homologous_superfamily | IPR012676 | TGS-like |
| Homologous_superfamily | IPR018163 | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily |
| Homologous_superfamily | IPR036621 | Anticodon-binding domain superfamily |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | Anticodon-binding | Anticodon-binding domain superfamily | Beta-grasp domain superfamily | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | TGS | TGS-like | Threonine-tRNA ligase catalytic core domain | Threonine-tRNA ligase, class IIa | Threonine-tRNA ligase, class IIa, anticodon-binding domain | Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily | Threonyl/alanyl tRNA synthetase, SAD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PXD7
|
563 | |||||||||||||
|
UniProtKB:A8KC60
|
718 | |||||||||||||
|
UniProtKB:Q5XIZ3
|
624 |
Interactions and Pathways
No data available
Plasmids
No data available