Gene
kctd15a
- ID
- ZDB-GENE-041010-105
- Name
- potassium channel tetramerization domain containing 15a
- Symbol
- kctd15a Nomenclature History
- Previous Names
-
- kctd15l
- fa02e12
- wu:fa02e12
- zgc:103747 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Acts upstream of with a negative effect on canonical Wnt signaling pathway. Acts upstream of or within several processes, including neural crest cell differentiation; pharyngeal system development; and regulation of RNA biosynthetic process. Is expressed in several structures, including ectoderm; nervous system; neural tube; presumptive ectoderm; and solid lens vesicle. Orthologous to human KCTD15 (potassium channel tetramerization domain containing 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103747 (38 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| y584 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kctd15a | (2) | |
| CRISPR2-kctd15a | (2) | |
| CRISPR3-kctd15a | Chambers et al., 2020 | |
| CRISPR4-kctd15a | Chambers et al., 2020 | |
| MO1-kctd15a | N/A | Dutta et al., 2010 |
| MO2-kctd15a | N/A | Chambers et al., 2020 |
| TALEN1-kctd15a | Heffer et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR003131 | Potassium channel tetramerisation-type BTB domain |
| Domain | IPR045904 | KCTD15, tetramerisation-type BTB domain |
| Domain | IPR048595 | BTB/POZ domain-containing protein KCTD1/15-like, C-terminal domain |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | BTB/POZ domain-containing protein KCTD1/15-like, C-terminal domain | KCTD15, tetramerisation-type BTB domain | Potassium channel tetramerisation-type BTB domain | SKP1/BTB/POZ domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:G1K2P0 | InterPro | 224 | |||||
| UniProtKB:A0A8M2BA73 | InterPro | 265 | |||||
| UniProtKB:A0A8M2BA07 | InterPro | 265 | |||||
| UniProtKB:Q5XJ34 | InterPro | 257 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kctd15a-201
(1)
|
Ensembl | 953 nt | ||
| mRNA |
kctd15a-202
(1)
|
Ensembl | 3,179 nt | ||
| mRNA |
kctd15a-203
(1)
|
Ensembl | 1,328 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.5kctd15a:GFP) |
|
| 1 | Heffer et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-269C21 | ZFIN Curated Data | |
| Encodes | EST | fa02e12 | ||
| Encodes | cDNA | MGC:103747 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001006012 (1) | 3482 nt | ||
| Genomic | GenBank:BX255962 (2) | 143935 nt | ||
| Polypeptide | UniProtKB:A0A8M2BA07 (1) | 265 aa |
- Chambers, B.E., Clark, E.G., Gatz, A.E., Wingert, R.A. (2020) Kctd15 regulates nephron segment development by repressing Tfap2a activity. Development (Cambridge, England). 147(23):
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Heffer, A., Marquart, G.D., Aquilina-Beck, A., Saleem, N., Burgess, H.A., Dawid, I.B. (2017) Generation and characterization of Kctd15 mutations in zebrafish. PLoS One. 12:e0189162
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Patil, P., Kibiryeva, N., Uechi, T., Marshall, J., O'Brien, J.E., Artman, M., Kenmochi, N., Bittel, D.C. (2015) scaRNAs Regulate Splicing and Vertebrate Heart Development. Biochimica et biophysica acta. Molecular basis of disease. 1852(8):1619-29
- Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852
- Zarelli, V.E., and Dawid, I.B. (2013) Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. Proceedings of the National Academy of Sciences of the United States of America. 110(8):2870-2875
- Zarelli, V.E., and Dawid, I.B. (2013) The BTB-Containing Protein Kctd15 Is SUMOylated In Vivo. PLoS One. 8(9):e75016
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