Gene
stc2a
- ID
- ZDB-GENE-041008-14
- Name
- stanniocalcin 2a
- Symbol
- stc2a Nomenclature History
- Previous Names
-
- stc2
- fd13c01
- im:6908722
- wu:fd13c01
- zgc:136650
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables protein homodimerization activity. Predicted to be involved in intracellular calcium ion homeostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cleithrum; nervous system; neural tube; presumptive telencephalon; and pronephros. Orthologous to human STC2 (stanniocalcin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908722 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004978 | Stanniocalcin |
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Domain Details Per Protein
| Protein | Length | Stanniocalcin |
|---|---|---|
|
UniProtKB:Q5IRA7
|
283 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-277C7 | ZFIN Curated Data | |
| Encodes | EST | fd13c01 | ||
| Encodes | EST | IMAGE:6908722 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:136650 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158140 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194369 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194389 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001014827 (1) | 852 nt | ||
| Genomic | GenBank:CR812847 (1) | 230522 nt | ||
| Polypeptide | UniProtKB:Q5IRA7 (1) | 283 aa |
- Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
- Li, S., Liu, C., Goldstein, A., Xin, Y., Ke, C., Duan, C. (2021) Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a. Frontiers in cell and developmental biology. 9:662915
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Chou, M.Y., Lin, C.H., Chao, P.L., Hung, J.C., Cruz, S.A., Hwang, P.P. (2015) Stanniocalcin-1 Controls Ion Regulation Functions of Ion-transporting Epithelium Other than Calcium Balance. International journal of biological sciences. 11:122-32
- Shin, J., and Sohn, Y.C. (2009) cDNA cloning of Japanese flounder stanniocalcin 2 and its mRNA expression in a variety of tissues. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 153(1):24-29
- Shin, J., Oh, D., and Sohn, Y.C. (2006) Molecular characterization and expression analysis of stanniocalcin-1 in turbot (Scophthalmus maximus). General and comparative endocrinology. 147(2):214-221
- Hang, X., and Balment, R.J. (2005) Stanniocalcin in the euryhaline flounder (Platichthys flesus): Primary structure, tissue distribution, and response to altered salinity. General and comparative endocrinology. 144(2):188-195
- Luo, C.W., Pisarska, M.D., and Hsueh, A.J. (2005) Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology. 146(1):469-76
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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