adam17b

ID

ZDB-GENE-041001-199

Name

ADAM metallopeptidase domain 17b

Symbol

adam17b Nomenclature History

Previous Names

adam17 (1)
si:dkey-81b15.2 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable metalloendopeptidase activity. Predicted to be involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adam17b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neonatal inflammatory skin and bowel disease 1	Alliance	?Inflammatory skin and bowel disease, neonatal, 1	614328

Associated With adam17b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR001762	Disintegrin domain
Domain	IPR032029	ADAM17, membrane-proximal domain
Domain	IPR034025	ADAM10/ADAM17 catalytic domain
Family	IPR051489	Disintegrin and Metalloproteinase Domain-Containing
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036436	Disintegrin domain superfamily