Gene

adam17b

ID

ZDB-GENE-041001-199

Name

ADAM metallopeptidase domain 17b

Symbol

adam17b Nomenclature History

Previous Names

adam17 (1)
si:dkey-81b15.2 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity. Predicted to be involved in Notch signaling pathway and PMA-inducible membrane protein ectodomain proteolysis. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adam17b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Inflammatory skin and bowel disease, neonatal, 1	614328

Associated With adam17b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR001762	Disintegrin domain
Domain	IPR032029	ADAM17, membrane-proximal domain
Domain	IPR034025	ADAM10/ADAM17 catalytic domain
Family	IPR051489	Disintegrin and Metalloproteinase Domain-Containing
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036436	Disintegrin domain superfamily

Domain Details Per Protein

Protein	Length	ADAM10/ADAM17 catalytic domain	ADAM17, membrane-proximal domain	Disintegrin and Metalloproteinase Domain-Containing	Disintegrin domain	Disintegrin domain superfamily	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin
UniProtKB:U3JAD1 InterPro	843

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	adam17b-201 (1) Ensembl	Ensembl		3,149 nt	Select Tool
mRNA	adam17b-202 (1) Ensembl	Ensembl		2,424 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations