Gene

serpinf1

ID

ZDB-GENE-040912-2

Name

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

Symbol

serpinf1 Nomenclature History

Previous Names

zgc:92072 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and ovarian hyperstimulation syndrome. Is expressed in cleithrum; head mesenchyme; notochord; somite; and splanchnocranium. Orthologous to human SERPINF1 (serpin family F member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7136361 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With serpinf1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
osteogenesis imperfecta type 6	Alliance	Osteogenesis imperfecta, type VI	613982

Associated With serpinf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023795	Serpin, conserved site
Domain	IPR023796	Serpin domain
Domain	IPR033832	Pigment epithelium derived factor, serpin domain
Family	IPR000215	Serpin family
Homologous_superfamily	IPR036186	Serpin superfamily
Homologous_superfamily	IPR042178	Serpin superfamily, domain 1
Homologous_superfamily	IPR042185	Serpin superfamily, domain 2