Gene

hpdb

ID

ZDB-GENE-040808-62

Name

4-hydroxyphenylpyruvate dioxygenase b

Symbol

hpdb Nomenclature History

Previous Names

hpd
zgc:92456

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to localize to Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Is expressed in several structures, including ectoderm; epidermis; median fin fold; neurons; and otic vesicle. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92456 (10 images)
IMAGE:7162729 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hpdb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hawkinsinuria	Alliance	Hawkinsinuria	140350
tyrosinemia type III	Alliance	Tyrosinemia, type III	276710

Associated With hpdb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004360	Glyoxalase/fosfomycin resistance/dioxygenase domain
Domain	IPR037523	Vicinal oxygen chelate (VOC) domain
Domain	IPR041735	4-hydroxyphenylpyruvate dioxygenase, C-terminal
Domain	IPR041736	4-hydroxyphenylpyruvate dioxygenase, N-terminal
Family	IPR005956	4-hydroxyphenylpyruvate dioxygenase
Homologous_superfamily	IPR029068	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

Domain Details Per Protein

Protein	Length	4-hydroxyphenylpyruvate dioxygenase	4-hydroxyphenylpyruvate dioxygenase, C-terminal	4-hydroxyphenylpyruvate dioxygenase, N-terminal	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/fosfomycin resistance/dioxygenase domain	Vicinal oxygen chelate (VOC) domain
UniProtKB:Q6AZV8 InterPro	393

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	hpdb-201 (1) Ensembl	Ensembl		1,621 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations