Gene
aqp4
- ID
- ZDB-GENE-040724-152
- Name
- aquaporin 4
- Symbol
- aqp4 Nomenclature History
- Previous Names
-
- si:ch211-192k9.1
- zgc:100922
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Exhibits water transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to localize to basolateral plasma membrane and integral component of membrane. Human ortholog(s) of this gene implicated in Meniere's disease; blindness; neuromyelitis optica; optic neuritis; and temporal lobe epilepsy. Is expressed in several structures, including brain; eye; gill; integument; and pleuroperitoneal region. Orthologous to human AQP4 (aquaporin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
?Megalencephalic leukoencephalopathy with subcortical cysts 4, remitting | 620448 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Aquaporin-like | Aquaporin transporter | Major intrinsic protein | Major intrinsic protein, conserved site |
---|---|---|---|---|---|
UniProtKB:Q6AZD2
|
320 | ||||
UniProtKB:A0A2R8Q5A8
|
328 |
Interactions and Pathways
No data available
Plasmids
No data available