Gene

pdha1b

ID
ZDB-GENE-040718-96
Name
pyruvate dehydrogenase E1 subunit alpha 1b
Symbol
pdha1b Nomenclature History
Previous Names
  • fp73b04
  • wu:fp73b04
  • zgc:92705 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to localize to mitochondrial pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pdha1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pyruvate decarboxylase deficiency Alliance Pyruvate dehydrogenase E1-alpha deficiency 312170
Associated With pdha1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001017 Dehydrogenase, E1 component
Family IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
Family IPR050642 Pyruvate Dehydrogenase E1 Alpha Subunit
Homologous_superfamily IPR029061 Thiamin diphosphate-binding fold
Domain Details Per Protein
Protein Length Dehydrogenase, E1 component Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y Pyruvate Dehydrogenase E1 Alpha Subunit Thiamin diphosphate-binding fold
UniProtKB:E7F9W7 400
UniProtKB:Q6DGZ9 393
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pdha1b-201 (1) Ensembl 1,712 nt
mRNA pdha1b-202 (1) Ensembl 2,432 nt
mRNA pdha1b-203 (1) Ensembl 543 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations