Gene

cpsf2

ID

ZDB-GENE-040718-79

Name

cleavage and polyadenylation specific factor 2

Symbol

cpsf2 Nomenclature History

Previous Names

zgc:92484 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage; mRNA polyadenylation; and pre-mRNA cleavage required for polyadenylation. Predicted to act upstream of or within mRNA cleavage and mRNA processing. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92484 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpsf2 Human Ortholog

No data available

Associated With cpsf2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001279	Metallo-beta-lactamase
Domain	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain
Domain	IPR022712	Beta-Casp domain
Domain	IPR025069	Cleavage and polyadenylation specificity factor 2, C-terminal
Domain	IPR035639	CPSF2, metallo-hydrolase domain
Family	IPR027075	Cleavage and polyadenylation specificity factor subunit 2
Homologous_superfamily	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Details Per Protein

Protein	Length	Beta-Casp domain	Cleavage and polyadenylation specificity factor 2, C-terminal	Cleavage and polyadenylation specificity factor subunit 2	CPSF2, metallo-hydrolase domain	Metallo-beta-lactamase	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Zn-dependent metallo-hydrolase, RNA specificity domain
UniProtKB:F1QVV4 InterPro	790
UniProtKB:Q6DHE5 InterPro	790

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cpsf2-201 (1) Ensembl	Ensembl	2,675 nt	Select Tool ZFIN BLAST
mRNA	cpsf2-202 (1) Ensembl	Ensembl	1,938 nt	Select Tool ZFIN BLAST
mRNA	cpsf2-203 (1) Ensembl	Ensembl	6,406 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations