ZFIN is now using GRCz12tu for Genomic Data
Gene
dnase1
- ID
- ZDB-GENE-040718-423
- Name
- deoxyribonuclease I
- Symbol
- dnase1 Nomenclature History
- Previous Names
-
- zgc:92440 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to be located in extracellular region; nuclear envelope; and zymogen granule. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to several human genes including DNASE1 (deoxyribonuclease 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92440 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| systemic lupus erythematosus | Alliance | {Systemic lupus erythematosus, susceptibility to} | 152700 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Deoxyribonuclease I | Deoxyribonuclease I, active site | Endonuclease/exonuclease/phosphatase | Endonuclease/exonuclease/phosphatase superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q6DG72 | InterPro | 278 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnase1-201
(1)
|
Ensembl | 1,309 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers