Gene
rxrgb
- ID
- ZDB-GENE-040718-34
- Name
- retinoid X receptor, gamma b
- Symbol
- rxrgb Nomenclature History
- Previous Names
-
- nr2b3b (1)
- zgc:92183
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable nuclear receptor activity and retinoic acid-responsive element binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and retinoic acid receptor signaling pathway. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including Kupffer's vesicle; central nervous system; liver; paraxial mesoderm; and retina. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- bc075918 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR021780 | Nuclear/hormone receptor activator site AF-1 |
| Family | IPR000003 | Retinoid X receptor/HNF4 |
| Family | IPR001723 | Nuclear hormone receptor |
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Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear/hormone receptor activator site AF-1 | Nuclear hormone receptor family NR2 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoid X receptor/HNF4 | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B7K1
|
465 | ||||||||
|
UniProtKB:Q6DHP9
|
452 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260G14 | ZFIN Curated Data | |
| Encodes | EST | bc075918 | Bertrand et al., 2007 | |
| Encodes | EST | fa03b10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92183 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002345 (1) | 1846 nt | ||
| Genomic | GenBank:BX296562 (1) | 129328 nt | ||
| Polypeptide | UniProtKB:A0A8M2B7K1 (1) | 465 aa |
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Tao, J., Bai, C., Chen, Y., Zhou, H., Liu, Y., Shi, Q., Pan, W., Dong, H., Li, L., Xu, H., Tanguay, R., Huang, C., Dong, Q. (2020) Environmental relevant concentrations of benzophenone-3 induced developmental neurotoxicity in zebrafish. The Science of the total environment. 721:137686
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Lin, S.J., Chiang, M.C., Shih, H.Y., Chiang, K.C., Cheng, Y.C. (2017) Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Development genes and evolution. 227(3):219-230
- Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130
- Cheng, J., Lv, S., Nie, S., Liu, J., Tong, S., Kang, N., Xiao, Y., Dong, Q., Huang, C., Yang, D. (2016) Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 176:45-52
- Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2016) Danio rerio embryos on Prozac - Effects on the detoxification mechanism and embryo development. Aquatic toxicology (Amsterdam, Netherlands). 178:182-189
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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