Gene
rhocb
- ID
- ZDB-GENE-040718-144
- Name
- ras homolog family member Cb
- Symbol
- rhocb Nomenclature History
- Previous Names
-
- rhoad
- zgc:92350
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in dorsal aorta; intersegmental vessel; neural tube; and posterior cardinal vein. Orthologous to human RHOC (ras homolog family member C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016330Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa27222 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rhocb | N/A | (2) |
| MO2-rhocb | N/A | Hoeppner et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|
|
UniProtKB:Q6DHE8
|
193 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-254N4 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-38G6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92350 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002445 (1) | 1065 nt | ||
| Genomic | GenBank:AL954868 (2) | 194224 nt | ||
| Polypeptide | UniProtKB:Q6DHE8 (1) | 193 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Salas-Vidal et al., (2005) report orthology to human RHOA. Subsequent analysis suggests this zebrafish gene is the ortholog of human RHOC and mouse Rhoc based on amino acid identity and conserved location. A phylogenetic tree also suggests orthology to RHOC and Rhoc.
- Yang, S., Zhang, X., Li, X., Yin, X., Teng, L., Ji, G., Li, H. (2022) Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. International Journal of Molecular Sciences. 23(14):
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Goodman, L., Zallocchi, M. (2017) Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells. Journal of Cell Science. 130:3698-3712
- D'Aurizio, R., Russo, F., Chiavacci, E., Baumgart, M., Groth, M., D'Onofrio, M., Arisi, I., Rainaldi, G., Pitto, L., Pellegrini, M. (2016) Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Frontiers in bioengineering and biotechnology. 4:60
- Hoeppner, L.H., Sinha, S., Wang, Y., Bhattacharya, R., Dutta, S., Gong, X., Bedell, V.M., Suresh, S., Chun, C.Z., Ramchandran, R., Ekker, S.C., Mukhopadhyay, D. (2015) RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. Journal of Cell Science. 128(19):3556-68
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Witzel, S., Zimyanin, V., Carreira-Barbosa, F., Tada, M., and Heisenberg, C.P. (2006) Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. The Journal of cell biology. 175(5):791-802
- Salas-Vidal, E., Meijer, A.H., Cheng, X., and Spaink, H.P. (2005) Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Genomics. 86(1):25-37
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