Gene

akr1b1.1

ID
ZDB-GENE-040625-7
Name
aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1
Symbol
akr1b1.1 Nomenclature History
Previous Names
  • akr1b1
  • zgc:86611 (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have alditol:NADP+ 1-oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Dooley et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With akr1b1.1 Human Ortholog
No data available
Associated With akr1b1.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018170 Aldo/keto reductase, conserved site
Domain IPR023210 NADP-dependent oxidoreductase domain
Family IPR020471 Aldo-keto reductase
Homologous_superfamily IPR036812 NADP-dependent oxidoreductase domain superfamily
Domain Details Per Protein
Protein Length Aldo-keto reductase Aldo/keto reductase, conserved site NADP-dependent oxidoreductase domain NADP-dependent oxidoreductase domain superfamily
UniProtKB:Q6IQU1 315
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations