Gene
rnf14
- ID
- ZDB-GENE-040625-65
- Name
- ring finger protein 14
- Symbol
- rnf14 Nomenclature History
- Previous Names
-
- ARA54 (1)
- wu:fb80d11
- wu:fi42d09
- zgc:86928
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RNF14 (ring finger protein 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151369 (1 image)
- IMAGE:6906030 (1 image)
- IMAGE:7157665 (1 image)
- bc071542 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17780 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin ligase RBR family | E3 ubiquitin-protein ligase RNF14, Rcat domain | E3 ubiquitin-protein ligase RNF14, RING finger, HC subclass | IBR domain | RWD domain | TRIAD supradomain | Ubiquitin-conjugating enzyme/RWD-like | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RB95 | InterPro | 459 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-119C15 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-207P11 | ZFIN Curated Data | |
| Contains | SNP | rs3729141 | ZFIN Curated Data | |
| Contains | SNP | rs3729142 | ZFIN Curated Data | |
| Contains | SNP | rs3729143 | ZFIN Curated Data | |
| Contains | SNP | rs3729144 | ZFIN Curated Data | |
| Contains | SNP | rs3729145 | ZFIN Curated Data | |
| Encodes | EST | bc071542 | Bertrand et al., 2007 | |
| Encodes | EST | fb80d11 | ||
| Encodes | EST | fi42d09 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002087 (1) | 2059 nt | ||
| Genomic | GenBank:CU459117 (1) | 38337 nt | ||
| Polypeptide | UniProtKB:F1RB95 (1) | 459 aa |
- De Meulemeester, A.S., Heylen, L., Siekierska, A., Mills, J.D., Romagnolo, A., Van Der Wel, N.N., Aronica, E., de Witte, P.A.M. (2022) Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities. Frontiers in cell and developmental biology. 10:952832
- Horzmann, K.A., Reidenbach, L.S., Thanki, D.H., Winchester, A.E., Qualizza, B.A., Ryan, G.A., Egan, K.E., Hedrick, V.E., Sobreira, T.J.P., Peterson, S.M., Weber, G.J., Wirbisky-Hershberger, S.E., Sepúlveda, M.S., Freeman, J.L. (2018) Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures. Journal of proteomics. 186:71-82
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wu, B., Piloto, S., Zeng, W., Hoverter, N.P., Schilling, T.F., and Waterman, M.L. (2013) Ring Finger Protein 14 is a new regulator of TCF/β‐catenin‐mediated transcription and colon cancer cell survival. EMBO reports. 14(4):347-55
- Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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