Gene
arhgef18a
- ID
- ZDB-GENE-040516-14
- Name
- rho/rac guanine nucleotide exchange factor (GEF) 18a
- Symbol
- arhgef18a Nomenclature History
- Previous Names
-
- arhgef18
- wu:fc21e04
- wu:fj05f11
- zgc:85686
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have guanyl-nucleotide exchange factor activity. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Retinitis pigmentosa 78 | 617433 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000219 | Dbl homology (DH) domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR041020 | ARHGEF1-like, PH domain |
| Family | IPR051632 | Rho guanine nucleotide exchange factor |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
Domain Details Per Protein
| Protein | Length | ARHGEF1-like, PH domain | Dbl homology (DH) domain | Dbl homology (DH) domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Rho guanine nucleotide exchange factor |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NSP2
|
940 | ||||||
|
UniProtKB:A0A8M3AXD6
|
940 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef18a-201
(1)
|
Ensembl | 4,184 nt | ||
| mRNA |
arhgef18a-202
(1)
|
Ensembl | 389 nt | ||
| mRNA |
arhgef18a-203
(1)
|
Ensembl | 554 nt |
Interactions and Pathways
No data available
Plasmids
No data available