Gene
serpine2
- ID
- ZDB-GENE-040426-848
- Name
- serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
- Symbol
- serpine2 Nomenclature History
- Previous Names
-
- zgc:55929
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of plasminogen activation. Predicted to be active in extracellular space. Is expressed in midbrain hindbrain boundary; neural plate; olfactory system; otic vesicle; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55929 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019423Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa993 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6397 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42621 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVL5
|
395 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpine2-201
(1)
|
Ensembl | 1,609 nt | ||
| mRNA |
serpine2-202
(1)
|
Ensembl | 1,191 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-123J12 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-398D16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55929 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191136 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200184 (1) | 1586 nt | ||
| Genomic | GenBank:CU657924 (2) | 41330 nt | ||
| Polypeptide | UniProtKB:Q7ZVL5 (1) | 395 aa |
- Jimenez, E., Slevin, C.C., Song, W., Chen, Z., Frederickson, S.C., Gildea, D., Wu, W., Elkahloun, A.G., Ovcharenko, I., Burgess, S.M. (2022) A regulatory network of Sox and Six transcription factors initiate a cell fate transformation during hearing regeneration in adult zebrafish. Cell genomics. 2(9):
- Han, S., Fei, F., Sun, S., Zhang, D., Dong, Q., Wang, X., Wang, L. (2020) Increased anxiety was found in serpini1 knockout zebrafish larval. Biochemical and Biophysical Research Communications. 534:1013-1019
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Yao, Q., Wang, L., Mittal, R., Yan, D., Richmond, M.T., Denyer, S., Requena, T., Liu, K., Varshney, G.K., Lu, Z., Liu, X. (2019) Transcriptomic Analyses of Inner Ear Sensory Epithelia in Zebrafish. Anatomical record (Hoboken, N.J. : 2007). 303(3):527-543
- Dogra, D., Ahuja, S., Kim, H.T., Rasouli, S.J., Stainier, D.Y.R., Reischauer, S. (2017) Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair. Nature communications. 8:1902
- Duan, Z., Xing, Y., Feng, Z., Zhang, H., Li, C., Gong, Z., Wang, L., Sun, H. (2017) Hepatotoxicity of benzotriazole and its effect on the cadmium induced toxicity in zebrafish Danio rerio. Environmental pollution (Barking, Essex : 1987). 224:706-713
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, C., Xu, H., Lam, S.H., and Gong, Z. (2013) Selection of Reliable Biomarkers from PCR Array Analyses Using Relative Distance Computational Model: Methodology and Proof-of-Concept Study. PLoS One. 8(12):e83954
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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